Faculty Collaboration Database

Near-Infrared Photobiomodulation in Retinal Injury and Disease. Adv Exp Med Biol 2016;854:437-41

Date

10/03/2015

Pubmed ID

26427443

DOI

10.1007/978-3-319-17121-0_58

Scopus ID

2-s2.0-84943327791 (requires institutional sign-in at Scopus site)   44 Citations

Abstract

Evidence is growing that exposure of tissue to low energy photon irradiation in the far-red (FR) to near-infrared (NIR) range of the spectrum, collectively termed "photobiomodulation" (PBM) can restore the function of damaged mitochondria, upregulate the production of cytoprotective factors and prevent apoptotic cell death. PBM has been applied clinically in the treatment of soft tissue injuries and acceleration of wound healing for more than 40 years. Recent studies have demonstrated that FR/NIR photons penetrate diseased tissues including the retina. The therapeutic effects of PBM have been hypothesized to result from intracellular signaling pathways triggered when FR/NIR photons are absorbed by the mitochondrial photoacceptor molecule, cytochrome c oxidase, culminating in improved mitochondrial energy metabolism, increased cytoprotective factor production and cell survival. Investigations in rodent models of methanol-induced ocular toxicity, light damage, retinitis pigmentosa and age-related macular degeneration have demonstrated the PBM attenuates photoreceptor cell death, protects retinal function and exerts anti-inflammatory actions.

Author List

Eells JT, Gopalakrishnan S, Valter K

Authors

Janis Eells PhD Professor in the Biomedical Sciences department at University of Wisconsin - Milwaukee
Sandeep Gopalakrishnan MS, PhD Assistant Professor and Director, Biobehavioral Research Laboratory in the College of Nursing department at University of Wisconsin - Milwaukee

MESH terms used to index this publication - Major topics in bold

Animals
Cell Survival
Disease Models, Animal
Electron Transport Complex IV
Electroretinography
Energy Metabolism
Humans
Infrared Rays
Methanol
Mice
Mitochondria
Photons
Photoreceptor Cells, Vertebrate
Phototherapy
Rats
Retina
Retinal Diseases