Plasma alpha-cell glucagon in primary hyperparathyroidism. Metabolism 1976 Jul;25(7):769-75
Date
07/01/1976Pubmed ID
781468DOI
10.1016/0026-0495(76)90148-7Scopus ID
2-s2.0-0017068007 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
Plasma glucose, insulin, and alpha-cell glucagon profiles were examined in ten adults with uncomplicated primary hyperparathyroidism before and 8-12 week after surgical removal of a single parathyroid adenoma. Treatment restored abnormal serum calcium and phosphorus concentrations to a normal range and reduced serum parathyroid hormone levels from 47 +/- 4 to 16 +/- 4 mu 1 Eq/ml (normal = 0-40). Plasma glucose curves during 100-g oral glucose tolerance, 30 min intravenous glucose (1.5 g/min), or arginine infusions (1.0 g/min) did not differ before and after surgery. However, basal and peak insulin concentrations were higher before treatment during these tests (p less than 0.05). Basal glucagon levels were unaffected by hyperparathyroidism (72 +/- 7 versus 77 +/- 7 pg/ml). Peak 30 min values after arginine provocation were also similar before and after treatment as was maximal suppression of basal glucagon during glucose infusions. Four patients also received 400 g lean beef meals. Glucose and glucagon responses over 240-min periods were nearly identical before and after surgery despite higher insulin levels before treatment. It is concluded that elevated serum parathyroid hormone and plasma insulin concentrations in primary hyperparathyroidism do not relate to abnormalities of plasma alpha-cell glucagon in the basal state or after glucose, arginine, or protein administration.
Author List
Kalkhoff RK, Gossain VV, Matute ML, Wilson SDMESH terms used to index this publication - Major topics in bold
AdultAged
Arginine
Blood Glucose
Clinical Trials as Topic
Female
Glucagon
Glucose Tolerance Test
Humans
Hyperinsulinism
Hyperparathyroidism
Insulin
Islets of Langerhans
Male
Middle Aged
Proteins
