Antitumor effects on primary tumor and metastatic lymph nodes by superselective intra-arterial concurrent chemoradiotherapy for oral cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010 Aug;110(2):172-7
Date
04/13/2010Pubmed ID
20382050DOI
10.1016/j.tripleo.2009.12.040Scopus ID
2-s2.0-77955431950 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
OBJECTIVE: Superselective intra-arterial infusion of anticancer agents with concurrent delivery of external beam radiotherapy was applied to 13 previously untreated cases of oral cancer for the purpose of avoiding surgical resection of the primary tumor.
STUDY DESIGN: The catheter tips were placed in the tumor feeder arteries via the superficial temporal artery and/or occipital artery. The catheters were retained for 6 weeks to infuse anticancer agents daily with concurrent radiotherapy for 6 weeks. The total radiation doses to the primary tumor and neck were 60.0 Gy and 40.0 Gy, respectively.
RESULTS: Complete response of the primary tumor was achieved in all 13 patients; complete response of neck node metastasis was achieved in 5 out of 6 patients.
CONCLUSION: This strategy is quite effective for oral cancer at both the primary site and metastatic lymph nodes, and it has the potential to be curative in advanced cases that are inoperable.
Author List
Uehara M, Shiraishi T, Tobita T, Nonaka M, Asahina IAuthor
Test W. User test user title in the Anesthesiology department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
AdultAged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Squamous Cell
Catheterization
Combined Modality Therapy
Humans
Infusions, Intra-Arterial
Lymph Nodes
Lymphatic Metastasis
Middle Aged
Mouth Neoplasms
Neck
Neoplasm Staging
Remission Induction
Temporal Arteries
Treatment Outcome
