Brain tumors: localized H-1 MR spectroscopy at 0.5 T. Radiology 1997 Jul;204(1):235-8
Date
07/01/1997Pubmed ID
9205253DOI
10.1148/radiology.204.1.9205253Scopus ID
2-s2.0-0031001497 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
PURPOSE: To investigate the feasibility of obtaining clinically useful magnetic resonance (MR) spectra at 0.5 T in cerebral lesions.
MATERIALS AND METHODS: Single-voxel localized proton MR spectroscopy was performed at 0.5 T in 18 patients (aged 16-73 years) suspected of having cerebral lesions on MR images who subsequently underwent craniotomy and biopsy and in eight volunteers (aged 21-50 years). The metabolite resonances in the MR spectra were stratified according to the histologic diagnosis. MR spectra demonstrated resonances for choline-containing compounds (Cho), creatine and phosphocreatine, glutamine and glutamate, N-acetylaspartate (NAA), myo-inositol, and lactate.
RESULTS: In 14 of 15 patients with cerebral tumors, the Cho-NAA ratio was increased and was greater than 1. In three patients with nonneoplastic cerebral lesions, the ratio did not exceed 1. In healthy control subjects, the average ratio was 0.54.
CONCLUSION: H-1 MR spectroscopy at 0.5 T provides clinically useful information in patients with cerebral lesions.
Author List
Prost R, Haughton V, Li SJMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Aspartic Acid
Biopsy
Brain Chemistry
Brain Neoplasms
Case-Control Studies
Choline
Feasibility Studies
Female
Humans
Magnetic Resonance Spectroscopy
Male
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Signal Processing, Computer-Assisted
