Does hyperparathyroidism cause hypergastrinemia? Surgery 1976 Aug;80(2):231-7
Date
08/01/1976Pubmed ID
941095Scopus ID
2-s2.0-0017198396 (requires institutional sign-in at Scopus site) 28 CitationsAbstract
To define the relationship between hyperparathyroidism (HPT) and gastric function, 31 patients with HPT were prospectively studied before and 2 to 25 months after parathyroidectomy. The gastrin response to a standard test meal (STM), the basal acid output (BAO), and the peak acid output (PAO) were determined. Parathormone and calcium were elevated in all patients and returned to normal following parathyroidectomy. The mean fasting gastrin concentration, mean integrated gastrin response (IGR) to feeding, mean basal acid output (BAO), and mean peak acid output (PAO) were not changed by successful parathyroidectomy. There was no significant correlation between gastrin concentration or gastrin response to feeding and gastric acid secretion. Eight of 31 HPT patients had fasting gastrin concentrations above normal preoperatively and remained so postoperatively. Hypergastrinemia in six of these eight patients could be explained by the Zollinger-Ellison (Z-E) syndrome or chronic atrophic gastritis. The hypothesis that peptic ulcer disease seen in some HPT patients is the result of calcium-induced hypergastrinemia causing gastric hypersecretion is not supported by this study.
Author List
Wilson SD, Singh RB, Kalkhoff RKMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Calcium
Female
Food
Gastric Juice
Gastrins
Humans
Hyperparathyroidism
Male
Middle Aged
Parathyroid Glands
Parathyroid Hormone
Phosphorus
Radioimmunoassay
Zollinger-Ellison Syndrome
