Faculty Collaboration Database

Distribution of Thyroliberin (TRH)- and 12-O-tetradecanoylphorbol 13-acetate (TPA)-activated adenylyl cyclase in normal and neoplastic tissue with special reference to the prostate. Mol Cell Endocrinol 1988 Aug;58(2-3):287-90

Date

08/01/1988

Pubmed ID

3145232

DOI

10.1016/0303-7207(88)90167-0

Scopus ID

2-s2.0-0023681301 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

Tissue specificity of the Thyroliberin (TRH)- and 12-O-tetradecanoylphorbol 13-acetate (TPA)-sensitive adenylyl cyclase has been studied using normal or neoplastic organ samples or cells from the pituitary gland, stomach, prostate, myocardium, liver and bone. It appeared that TRH stimulates the adenylyl cyclase in both normal (basal cells), hyperplastic and adenocarcinomatous prostate as well as in the pituitary and stomach. TPA also stimulated the enzyme from the prostate and other organs/cells, but to a greater extent in neoplastic tissue. Functional links from protein kinase C to adenylyl cyclase and from protein kinase C to tyrosine kinase/oncogene expression have been established. Hence it is believed that TRH, which stimulates the adenylyl cyclase and protein kinase C in the pituitary, may serve as a factor contributing to transformation of prostatic cells or enhanced cell proliferation in prostatic cancer.

Author List

Gordeladze JO, Rur H, Attramadal A, Tveter K, Gautvik KM, Purvis K

MESH terms used to index this publication - Major topics in bold

Adenylyl Cyclases
Animals
Humans
Male
Phorbol Esters
Pituitary Gland
Prostate
Prostatic Neoplasms
Rats
Stomach
Tetradecanoylphorbol Acetate
Thyrotropin-Releasing Hormone