Effect of linoleic acid infusion on blood pressure in normotensive and hypertensive rats. Am J Physiol 1989 Aug;257(2 Pt 2):H611-7
Date
08/01/1989Pubmed ID
2764141DOI
10.1152/ajpheart.1989.257.2.H611Scopus ID
2-s2.0-0024459027 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
High dietary intake of linoleic acid lowers arterial pressure, and, in vitro, linoleic acid inhibits the enzymatic activity of renin. The purpose of the present study was 1) to evaluate the effect of intravenous infusion of linoleic acid on blood pressure in normotensive and hypertensive Sprague-Dawley rats and 2) to determine whether the hypotensive response to linoleic acid infusion is caused by inhibition of circulating renin. Blood pressure was decreased (P less than 0.01) by linoleic acid infusion in normotensive sodium chloride-deprived animals and in animals with two-kidney, one-clip hypertension. In contrast, linoleic acid infusion did not affect blood pressure in normotensive rats on a "normal" or high sodium chloride intake, in rats with deoxycorticosterone acetate (DOCA)-salt hypertension, and in anephric rats. In sodium chloride-deprived rats, the reduction of blood pressure by linoleic acid infusion was associated with increased plasma renin activity (P less than 0.05); serum angiotensin-converting enzyme activity was unchanged. The in vitro enzymatic activity of exogenous renin in plasma of anephric rats was not affected by linoleic acid infusion. In two-kidney, one-clip hypertensive animals, pretreatment with indomethacin did not alter the hypotensive response to linoleic acid. Thus, although linoleic acid infusion lowered blood pressure in high renin but not in low renin states, the reduction of blood pressure was not related to inhibition of circulating renin or to alterations of endogenous prostaglandin biosynthesis.
Author List
Reddy SR, Talwalkar R, Downs J, Kotchen TAMESH terms used to index this publication - Major topics in bold
AnimalsBlood Pressure
Hypertension
Hypertension, Renovascular
Infusions, Intravenous
Linoleic Acid
Linoleic Acids
Male
Oleic Acid
Oleic Acids
Rats
Rats, Inbred Strains
Reference Values
