The carotid chemoreceptors are a major determinant of ventilatory CO2 sensitivity and of PaCO2 during eupneic breathing. Adv Exp Med Biol 2008;605:322-6
Date
12/19/2007Pubmed ID
18085293DOI
10.1007/978-0-387-73693-8_56Scopus ID
2-s2.0-38449120825 (requires institutional sign-in at Scopus site) 38 CitationsAbstract
Both carotid and intracranial chemoreceptors are critical to a normal ventilatory CO2-H+ chemosensitivity. At low levels of hypercapnia, the carotid contribution is probably greater than the central contribution but, at high levels, the intracranial chemoreceptors are dominant. The carotid chemoreceptors are also critical to maintaining a stable and normal eupneic PaCO2, but lesion-induced attenuation of intracranial CO2-H+ chemosensitivity does not consistently alter eupneic PaCO2. A major unanswered question is why do intracranial chemoreceptors in carotid body denervation (CBD) animals tolerate an acidosis during eupnea which prior to CBD elicits a marked increase in breathing.
Author List
Forster HV, Martino P, Hodges M, Krause K, Bonis J, Davis S, Pan LAuthors
Hubert V. Forster PhD Professor in the Physiology department at Medical College of WisconsinMatthew R. Hodges PhD Professor in the Physiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsBrain
Carbon Dioxide
Carotid Body
Chemoreceptor Cells
Humans
Hypercapnia
Models, Animal
Respiratory Physiological Phenomena
