Faculty Collaboration Database

Polyhydroxylated fullerenols regulate macrophage for cancer adoptive immunotherapy and greatly inhibit the tumor metastasis. Nanomedicine 2016 May;12(4):945-954

Date

01/07/2016

Pubmed ID

26733256

DOI

10.1016/j.nano.2015.11.021

Scopus ID

2-s2.0-84961279249 (requires institutional sign-in at Scopus site)   57 Citations

Abstract

UNLABELLED: Adoptive immunotherapy is a highly effective approach for cancer treatment. Several potential adoptive immunotherapies have high (though reversible) toxicities with disappointing results. Polyhydroxylated fullerenols have been demonstrated as promising antitumor drugs with low toxicities. In this study, we investigate whether polyhydroxylated fullerenols (C60(OH)22 and Gd@C82(OH)22) contribute to cancer immunotherapy by regulating macrophages. Our results show that fullerenols treatment enhances mitochondrial metabolism, phagocytosis and cytokine secretion. Moreover, activated macrophages inhibit the growth of several cancer cell types. It is likely that this inhibition is dependent on an NF-κB-mediated release of multiple cytokines. Using a lung metastasis model, we also show that autologous macrophages greatly suppress cancer cell metastasis to lung when they are activated by C60(OH)22 and Gd@C82(OH)22. More importantly, Gd@C82(OH)22 are shown to have stronger ability than C60(OH)22 to improve the macrophage function, which shed light on the rational design for nanomedicine and clinical application.

FROM THE CLINICAL EDITOR: The interest in the use of immunotherapy in cancer has rekindled recently. However, many approaches have shown disappointing results. In this study, the authors investigated the effects of polyhydroxylated fullerenol nanoparticles on regulating macrophages for immunotherapy. These positive findings may point a novel way to cancer treatment.

Author List

Tang J, Chen Z, Sun B, Dong J, Liu J, Zhou H, Wang L, Bai R, Miao Q, Zhao Y, Chen C, Liu Y

MESH terms used to index this publication - Major topics in bold

Animals
Antineoplastic Agents
Cell Line, Tumor
Cytokines
Fullerenes
Gadolinium
Humans
Immunotherapy, Adoptive
Macrophages
Mice
Mitochondria
Nanoparticles
Neoplasm Metastasis
Neoplasms