Diabetes enhances vasoreactivity to calcium entry blockers. Artery 1989;16(5):263-71
Date
01/01/1989Pubmed ID
2764731Scopus ID
2-s2.0-0024446472 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
Equipotent concentrations of diltiazem and verapamil relaxed coronary resistance vessels in isovolumically-perfused rat hearts. In diabetic hearts, the vasodilator response to diltiazem, and to a lesser extent verapamil, was significantly augmented. The addition of both calcium entry blockers also produced greater relaxation in precontracted isolated thoracic aorta of diabetic animals suggesting that diabetes increases the sensitivity of calcium entry blockers in two separate vessel types.
Author List
Pieper GM, Gross GJMESH terms used to index this publication - Major topics in bold
AnimalsAorta, Thoracic
Diabetes Mellitus, Experimental
Diltiazem
Heart
In Vitro Techniques
Male
Muscle Contraction
Muscle, Smooth, Vascular
Rats
Rats, Inbred Strains
Reference Values
Vascular Resistance
Verapamil
