Synovial fluid inorganic pyrophosphate concentration and nucleotide pyrophosphohydrolase activity in basic calcium phosphate deposition arthropathy and Milwaukee shoulder syndrome. Arthritis Rheum 1988 Mar;31(3):408-13
Date
03/01/1988Pubmed ID
2833903DOI
10.1002/art.1780310313Scopus ID
2-s2.0-0023928685 (requires institutional sign-in at Scopus site) 52 CitationsAbstract
Synovial fluid (SF) inorganic pyrophosphate (PPi) concentration is elevated in calcium pyrophosphate dihydrate (CPPD) crystal deposition arthropathy. Since CPPD and basic calcium phosphate (BCP) crystals often are present in the same joints, we determined [PPi] and activity of the PPi-generating enzyme, nucleotide pyrophosphohydrolase (NPPH), in SF from the joints of patients with various arthropathies, including those with BCP crystals. We found elevated SF [PPi] in joints with BCP crystals, as well as in joints with CPPD crystals. The presence of BCP crystals in synovial fluids was also predictive of elevated NPPH activity.
Author List
Rachow JW, Ryan LM, McCarty DJ, Halverson PCMESH terms used to index this publication - Major topics in bold
Calcium PhosphatesCrystallization
Diphosphates
Humans
Joint Diseases
Osmolar Concentration
Osteoarthritis
Preservation, Biological
Pyrophosphatases
Shoulder Joint
Syndrome
Synovial Fluid
