Long-term daily vibration exposure alters current perception threshold (CPT) sensitivity and myelinated axons in a rat-tail model of vibration-induced injury. J Toxicol Environ Health A 2016;79(3):101-11
Date
02/09/2016Pubmed ID
26852665DOI
10.1080/15287394.2015.1104272Scopus ID
2-s2.0-84960338085 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
Repeated exposure to hand-transmitted vibration through the use of powered hand tools may result in pain and progressive reductions in tactile sensitivity. The goal of the present study was to use an established animal model of vibration-induced injury to characterize changes in sensory nerve function and cellular mechanisms associated with these alterations. Sensory nerve function was assessed weekly using the current perception threshold test and tail-flick analgesia test in male Sprague-Dawley rats exposed to 28 d of tail vibration. After 28 d of exposure, Aβ fiber sensitivity was reduced. This reduction in sensitivity was partly attributed to structural disruption of myelin. In addition, the decrease in sensitivity was also associated with a reduction in myelin basic protein and 2',3'- cyclic nucleotide phosphodiasterase (CNPase) staining in tail nerves, and an increase in circulating calcitonin gene-related peptide (CGRP) concentrations. Changes in Aβ fiber sensitivity and CGRP concentrations may serve as early markers of vibration-induced injury in peripheral nerves. It is conceivable that these markers may be utilized to monitor sensorineural alterations in workers exposed to vibration to potentially prevent additional injury.
Author List
Krajnak K, Raju SG, Miller GR, Johnson C, Waugh S, Kashon ML, Riley DAMESH terms used to index this publication - Major topics in bold
AnimalsAxons
Calcitonin Gene-Related Peptide
Cyclic Nucleotide Phosphodiesterases, Type 1
Disease Models, Animal
Hand-Arm Vibration Syndrome
Male
Myelin Basic Protein
Peripheral Nerves
Rats
Rats, Sprague-Dawley
Tumor Necrosis Factor-alpha
Vibration
