Depth and Patterns of Adnexal Involvement in Primary Extramammary (Anogenital) Paget Disease: A Study of 178 Lesions From 146 Patients. Am J Dermatopathol 2016 Nov;38(11):802-808
Date
10/21/2016Pubmed ID
26863064DOI
10.1097/DAD.0000000000000552Scopus ID
2-s2.0-84957824082 (requires institutional sign-in at Scopus site) 28 CitationsAbstract
Extramammary Paget disease (EMPD) is a rare neoplasm usually presenting in the anogenital area, most commonly in the vulva. Adnexal involvement in primary EMPD is a very common feature and serves as a pathway for carcinoma to spread into deeper tissue. The depth of carcinomatous spread along the appendages and the patterns of adnexal involvement were studied in 178 lesions from 146 patients with primary EMPD. Hair follicles and eccrine ducts were the adnexa most commonly affected by carcinoma cells. The maximal depth of involvement was 3.6 mm in this series. When planning topical therapy or developing novel local treatment modalities for EMPD, this potential for significant deep spread along adnexa should be taken into account.
Author List
Konstantinova AM, Shelekhova KV, Stewart CJ, Spagnolo DV, Kutzner H, Kacerovska D, Plaza JA, Suster S, Bouda J, Pavlovsky M, Kyrpychova L, Michal M, Guenova E, Kazakov DVMESH terms used to index this publication - Major topics in bold
AdultAged
Aged, 80 and over
Anus Neoplasms
Biopsy
Eccrine Glands
Europe
Female
Hair Follicle
Humans
Male
Middle Aged
Neoplasms, Adnexal and Skin Appendage
Paget Disease, Extramammary
Prognosis
Sweat Gland Neoplasms
Vulvar Neoplasms
Western Australia
