Faculty Collaboration Database

Failure of antioxidant therapy (polyethylene glycol-conjugated catalase) in acute pancreatitis. Am J Surg 1989 Jan;157(1):145-9

Date

01/01/1989

Pubmed ID

2910119

DOI

10.1016/0002-9610(89)90437-6

Scopus ID

2-s2.0-0024520148 (requires institutional sign-in at Scopus site)   12 Citations

Abstract

Previous studies have demonstrated that intravenous catalase infusion protects against the formation of pancreatic edema in cerulein-induced acute pancreatitis; however, polyethylene glycol (PEG)-conjugated catalase given as a bolus was not protective. Using radiolabeled catalase and PEG-catalase in subtherapeutic tracer doses, the pancreas tissue distributions of each were determined in rats with and without pancreatitis. Rats with cerulein-induced pancreatitis developed tissue concentrations of catalase within the pancreas that were three times those of PEG-catalase. The relatively low levels of PEG-catalase in the pancreas outside of the vascular compartment suggest that the failure to prevent edema formation may result from inability of PEG-catalase to reach extravascular sites of injury because of the large molecular size.

Author List

Guice KS, Oldham KT, Johnson KJ

MESH terms used to index this publication - Major topics in bold

Acute Disease
Animals
Catalase
Ceruletide
Drug Combinations
Edema
Male
Pancreas
Pancreatic Diseases
Pancreatitis
Polyethylene Glycols
Rats
Rats, Inbred Strains