Lytic anti-endothelial cell antibodies in haemolytic-uraemic syndrome. Lancet 1988 Jul 23;2(8604):183-6
Date
07/23/1988Pubmed ID
2899661DOI
10.1016/s0140-6736(88)92287-8Scopus ID
2-s2.0-0023689408 (requires institutional sign-in at Scopus site) 163 CitationsAbstract
Sera from 13 of 14 children with acute haemolytic uraemic syndrome (HUS) contained complement-fixing IgG and IgM antibodies that lysed cultured human umbilical vein endothelial cells. In 3 of 3 sera tested, no lysis of dermal fibroblasts was observed. The endothelial cell antigen was lost after treatment of the cells with gamma interferon. In contrast, only 3 of 5 adult patients with acute, non-relapsing, thrombotic thrombocytopenic purpura (TTP) had lytic anti-endothelial antibodies and only 1 of these recognised an antigen lost upon gamma interferon treatment. None of 32 control sera contained lytic anti-endothelial cell antibodies. These data suggest that HUS involves a disorder of immunoregulation and that a unique class of anti-endothelial cell antibodies is produced that may take part in the pathogenesis of vascular injury in HUS.
Author List
Leung DY, Moake JL, Havens PL, Kim M, Pober JSMESH terms used to index this publication - Major topics in bold
AdultAutoantibodies
Child
Child, Preschool
Cytotoxicity, Immunologic
Endothelium, Vascular
Female
Hemolytic-Uremic Syndrome
Humans
Immunoglobulin G
Immunoglobulin M
Infant
Interferon-gamma
Male
Purpura, Thrombotic Thrombocytopenic
