Differential deoxyadenosine toxicity to immature rabbit cartilage in vitro. A model for the chondro-osseous dysplasia of adenosine deaminase deficiency. Arthritis Rheum 1989 Aug;32(8):1014-21
Date
08/01/1989Pubmed ID
2788422DOI
10.1002/anr.1780320811Scopus ID
2-s2.0-0024450234 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Deoxyadenosine metabolism was investigated in rabbit growth plate and articular cartilage to elucidate the biochemical basis for the chondro-osseous dysplasia observed in adenosine deaminase (ADA) deficiency. Models of ADA deficiency, the combination of deoxy-adenosine and either of 2 ADA inhibitors, were selectively toxic to immature cartilage, supporting the hypothesis that the chondro-osseous dysplasia of ADA deficiency is the consequence of the enzyme deficiency. Depletion of ATP may play a role in the altered chondrocyte viability and function observed in this model.
Author List
Wortmann RL, Veum JA, Ryan LM, Cheung HSMESH terms used to index this publication - Major topics in bold
Adenosine DeaminaseAdenosine Deaminase Inhibitors
Adenosine Triphosphate
Animals
Bone and Bones
Cartilage
Cell Survival
Deoxyadenosines
Disease Models, Animal
Nucleoside Deaminases
Purines
Rabbits
