Faculty Collaboration Database

Proceedings from the Second Haploidentical Stem Cell Transplantation Symposium-Haplo2014, San Francisco, California, December 4, 2014. Biol Blood Marrow Transplant 2016 Apr;22(4):594-604

Date

01/26/2016

Pubmed ID

26806585

Pubmed Central ID

PMC7104805

DOI

10.1016/j.bbmt.2016.01.001

Scopus ID

2-s2.0-84960481145 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

Significant progress has been made over the past decade in haploidentical transplantation, with the development of novel methods to control intense alloreactive reactions generated in the major HLA-mismatched setting. Application of post-transplantation cyclophosphamide has gained worldwide acceptance as an effective and low-cost way to perform this type of transplantation, with outcomes now similar to those from HLA-matched unrelated donors. These advances have resulted in improved treatment-related mortality, whereas disease relapse has emerged as the most common cause of treatment failure. In addition, improvements in immunologic reconstitution after transplantation are much needed, not only in haploidentical transplantation but in all forms of stem cell transplantation. This symposium has focused on some of the most promising methods to control alloreactivity in this form of transplantation and application of cellular therapy to prevent disease relapse after transplantation, as well as understanding immunologic reconstitution and foreseeable approaches to improve immune recovery after transplantation.

Author List

Al Malki MM, Horowitz M, Handgretinger R, Leung W, Roy DC, Huang XJ, Fuchs E, Locatelli F, Blaise D, Mineishi S, Martelli M, Miller J, June C, Ai HS, Luznik L, Mavilio D, Lugli E, van den Brink MRM, Champlin RE, Ciurea SO

Author

Mary M. Horowitz MD, MS Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Antineoplastic Agents, Alkylating
Clinical Trials as Topic
Cyclophosphamide
Disease Models, Animal
Graft vs Host Disease
HLA Antigens
Hematologic Neoplasms
Histocompatibility Testing
Humans
Mice
Recurrence
San Francisco
Secondary Prevention
Stem Cell Transplantation
Survival Analysis
T-Lymphocytes, Regulatory
Transplantation, Isogeneic
Unrelated Donors