Comparison of technetium-99m pyrophosphate and technetium-99m DTPA aerosols for SPECT ventilation lung imaging. J Nucl Med 1988 Nov;29(11):1761-7
Date
11/01/1988Pubmed ID
2846800Scopus ID
2-s2.0-0023686078 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
Although [99mTc] diethylenetriaminepentaacetic acid (DTPA) is currently the most widely used radioaerosol, rapid alveolar clearance limits its usefulness for single photon emission computed tomography (SPECT) ventilation lung imaging. Previous research has shown that [99mTc]phosphate compounds have high alveolar deposition and slow clearance and thus provide suitable aerosols for pulmonary ventilation studies. We have compared the pulmonary retention and blood levels of [99mTc]pyrophosphate (PYP) and [99mTc]DTPA in eight normal nonsmoking male volunteers. These two radioaerosols have comparable pulmonary deposition. Technetium-99m PYP, however, has a much slower pulmonary clearance which allows sufficient time (20 or more minutes) for SPECT data acquisition using a single-headed rotating gamma camera. While the radiation absorbed dose to the lungs for [99mTc]PYP (0.31 rad/mCi) is greater than for [99mTc]DTPA (0.11 rad/mCi), it is at a clinically acceptable and safe level.
Author List
Isitman AT, Collier BD, Palmer DW, Trembath L, Krasnow AZ, Rao SA, Hellman RS, Hoffmann RG, Peck DC, Dellis CJAuthor
Robert Hellman MD Emeritus Professor in the Radiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Administration, InhalationAdult
Aerosols
Diphosphates
Humans
Lung
Male
Organometallic Compounds
Pentetic Acid
Pulmonary Embolism
Technetium
Technetium Tc 99m Pentetate
Technetium Tc 99m Pyrophosphate
Tomography, Emission-Computed
