Faculty Collaboration Database

Factors Associated With Continuous Low-Dose Heparin Infusion for Central Venous Catheter Patency in Critically Ill Children Worldwide. Pediatr Crit Care Med 2016 Aug;17(8):e352-61

Date

07/01/2016

Pubmed ID

27362853

Pubmed Central ID

PMC4980163

DOI

10.1097/PCC.0000000000000854

Scopus ID

2-s2.0-84976603989 (requires institutional sign-in at Scopus site)   6 Citations

Abstract

OBJECTIVES: To identify patient, hospital, and central venous catheter factors that may influence the use of low-dose heparin infusion for central venous catheter patency in critically ill children.

DESIGN: Secondary analysis of an international multicenter observational study.

SETTING: Fifty-nine PICUs over four study dates in 2012, involving seven countries.

PATIENTS: Children less than 18 years old with a central venous catheter who were admitted to a participating unit and enrolled in the completed Prophylaxis against Thrombosis Practice study were included. All overflow patients were excluded.

INTERVENTIONS: None.

MEASUREMENTS AND MAIN RESULTS: Of the 2,484 patients in the Prophylaxis against Thrombosis Practice study, 1,312 patients had a central venous catheter. Five hundred seven of those patients used low-dose heparin infusion. The frequency of low-dose heparin infusion was compared across various patient, hospital, and central venous catheter factors using chi-square, Mann-Whitney U, and Fisher exact tests. In the multivariate analysis, age was not a significant factor for low-dose heparin infusion use. Patients with pulmonary hypertension had decreased low-dose heparin infusion use, whereas those with active surgical or trauma diagnoses had increased low-dose heparin infusion use. All centrally inserted central venous catheters were more likely to use low-dose heparin infusion when compared with peripherally inserted central venous catheters. The Asia-Pacific region showed increased low-dose heparin infusion use, along with community hospitals and smaller ICUs (< 10 beds).

CONCLUSIONS: Patient, central venous catheter, and hospital factors are associated with the use of low-dose heparin infusion in critically ill children. Further study is needed to evaluate the efficacy and persistence of low-dose heparin infusion use.

Author List

Onyeama SJ, Hanson SJ, Dasgupta M, Hoffmann RG, Faustino EV, Prophylaxis against Thrombosis Practice Study Investigators

MESH terms used to index this publication - Major topics in bold

Adolescent
Anticoagulants
Catheterization, Central Venous
Child
Child, Preschool
Critical Illness
Female
Healthcare Disparities
Heparin
Humans
Infant
Infant, Newborn
Infusions, Intravenous
Intensive Care Units, Pediatric
Male
Multivariate Analysis
Practice Patterns, Physicians'
Retrospective Studies
Venous Thromboembolism