Inhibition of renin by plasma linoleic acid. Am J Med Sci 1988 Sep;296(3):192-7
Date
09/01/1988Pubmed ID
3052059DOI
10.1097/00000441-198809000-00008Scopus ID
2-s2.0-0023810804 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
The authors have demonstrated previously that human plasma contains an inhibitor(s) of the enzymatic activity of renin. The purpose of this study is to identify the circulating renin inhibitor. Plasma initially was fractionated with preparative sephacryl S-300 chromatography. A fraction with low protein content inhibited the in vitro enzymatic activity of human renin by 76%. The inhibitory activity of this fraction was not altered by boiling and/or acidification. This fraction was applied to an affinity column, using purified mouse submaxillary renin as ligand. The inhibitor was recovered after elution with hypertonic NaCl. Linoleic acid, a previously identified renin inhibitor, was present in this fraction. The authors conclude that circulating linoleic acid inhibits renin. Conceivably, the overall activity of the renin-angiotensin-aldosterone cascade may be modified by alterations of plasma fatty acid concentrations.
Author List
Talwalkar RT, Kotchen TAMESH terms used to index this publication - Major topics in bold
Angiotensin IAnimals
Chromatography
Female
Humans
In Vitro Techniques
Linoleic Acids
Mice
Renin
Submandibular Gland
