Reciprocal effects of antidepressant treatment on activity and connectivity of the mood regulating circuit: an FMRI study. J Neuropsychiatry Clin Neurosci 2007;19(3):274-82
Date
09/11/2007Pubmed ID
17827412Pubmed Central ID
PMC3465666DOI
10.1176/jnp.2007.19.3.274Scopus ID
2-s2.0-34548074703 (requires institutional sign-in at Scopus site) 177 CitationsAbstract
It has been hypothesized that one of the effects of antidepressants is to increase functional connectivity between the cortical mood-regulating and the limbic mood-generating regions. One consequence of this antidepressant effect is thought to be decreased limbic activation in response to negative emotional stimuli. Twelve unmedicated unipolar depressed patients and 11 closely matched healthy comparison subjects completed two magnetic resonance imaging (MRI) scanning sessions at baseline and after 6 weeks. Depressed patients received treatment with sertraline between the two sessions. During each MRI session, subjects completed a resting state functional connectivity scan and a conventional block-design negative vs. neutral pictures regional brain activation scan. After 6 weeks of sertraline treatment resting state, functional connectivity between the ACC and limbic regions increased while limbic activation in response to negative versus neutral pictures decreased. The results of this study are consistent with the hypothesis that antidepressant treatment has reciprocal effects on corticolimbic functional connectivity and limbic activation in response to emotional stimuli.
Author List
Anand A, Li Y, Wang Y, Gardner K, Lowe MJAuthor
Yang Wang MD Professor in the Radiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Analysis of Variance
Antidepressive Agents
Brain Mapping
Case-Control Studies
Depression
Emotions
Gyrus Cinguli
Humans
Image Processing, Computer-Assisted
Limbic System
Magnetic Resonance Imaging
Middle Aged
Oxygen
Photic Stimulation
Sertraline
