National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Research Methodology and Study Design Working Group Report. Biol Blood Marrow Transplant 2017 Jan;23(1):10-23
Date
09/04/2016Pubmed ID
27590102Pubmed Central ID
PMC5182148DOI
10.1016/j.bbmt.2016.08.018Scopus ID
2-s2.0-84994430629 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
The increasing numbers of hematopoietic cell transplantations (HCTs) performed each year, the changing demographics of HCT recipients, the introduction of new transplantation strategies, incremental improvement in survival, and the growing population of HCT survivors demand a comprehensive approach to examining the health and well-being of patients throughout life after HCT. This report summarizes strategies for the conduct of research on late effects after transplantation, including consideration of the study design and analytic approaches; methodologic challenges in handling complex phenotype data; an appreciation of the changing trends in the practice of transplantation; and the availability of biospecimens to support laboratory-based research. It is hoped that these concepts will promote continued research and facilitate the development of new approaches to address fundamental questions in transplantation outcomes.
Author List
Shaw BE, Hahn T, Martin PJ, Mitchell SA, Petersdorf EW, Armstrong GT, Shelburne N, Storer BE, Bhatia SAuthor
Bronwen E. Shaw MBChB, PhD Center Director, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultDelivery of Health Care
Health Planning Guidelines
Hematopoietic Stem Cell Transplantation
Humans
Long Term Adverse Effects
Middle Aged
National Institutes of Health (U.S.)
Research Design
Time Factors
United States
Young Adult
