Faculty Collaboration Database

Pyoderma gangrenosum following breast reduction: treatment with topical tacrolimus and steroids. Aesthet Surg J 2014 Mar;34(3):394-9

Date

01/23/2014

Pubmed ID

24448967

DOI

10.1177/1090820X13520448

Scopus ID

2-s2.0-84899436979 (requires institutional sign-in at Scopus site)   18 Citations

Abstract

UNLABELLED: Pyoderma gangrenosum (PG) is a rare, noninfectious, inflammatory dermatosis usually associated with autoimmune disorders. Wounds may mimic a necrotizing infection, and the diagnosis is usually made after antibiotic therapy fails. Debridement may cause even larger wounds because of pathergy, so PG treatment consists of corticosteroids and local wound care. Pyoderma gangrenosum can be a devastating complication of breast and aesthetic surgery. We describe a case of PG following unilateral breast reduction that resulted in systemic inflammatory response; after treatment with prednisone and topical tacrolimus, the PG was resolved. The application of topical tacrolimus may reduce the need for prolonged corticosteroids.

LEVEL OF EVIDENCE: 5.

Author List

Doren EL, Aya-ay ML

MESH terms used to index this publication - Major topics in bold

Breast Diseases
Female
Glucocorticoids
Humans
Immunosuppressive Agents
Mammaplasty
Middle Aged
Prednisone
Pyoderma Gangrenosum
Tacrolimus
Treatment Outcome