Faculty Collaboration Database

Predicting cancer on excision of atypical ductal hyperplasia. Am J Surg 2008 Mar;195(3):358-61; discussion 361-2

Date

01/22/2008

Pubmed ID

18206849

DOI

10.1016/j.amjsurg.2007.11.008

Scopus ID

2-s2.0-40749097729 (requires institutional sign-in at Scopus site)   35 Citations

Abstract

BACKGROUND: There are no specific histopathologic factors that allow identification of patients with atypical ductal hyperplasia (ADH) who will have cancer on final excision.

METHODS: This was a retrospective study of all patients who had ADH on biopsy followed by excision from 1999 to 2006.

RESULTS: Fifty-one patients were found to have ADH on core biopsy. Eight (15.7%) patients had invasive carcinoma on surgical excision, 9 (17.5%) had ductal carcinoma-in-situ (DCIS), 21 (41.5%) had ADH, 4 (8%) patients had atypical lobular hyperplasia, and 9 (17.5%) had benign tumors. The grade of atypia on the core biopsy was mild in 13 (25%) patients, moderate in 22 (43%), and marked in 16 (32%). On multivariate analysis of histopathologic factors, the grade of atypia was the only significant variable that predicted a diagnosis of cancer on final surgical excision (P = .001).

CONCLUSIONS: The grade of atypia correlated with the presence of cancer on surgical excision.

Author List

Doren E, Hulvat M, Norton J, Rajan P, Sarker S, Aranha G, Yao K

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Aged, 80 and over
Biopsy
Breast
Breast Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Female
Humans
Hyperplasia
Middle Aged
Predictive Value of Tests
Retrospective Studies