Alterations in polyamine metabolism during embryonal carcinoma cell differentiation in vitro. Dev Biol 1985 Oct;111(2):510-4
Date
10/01/1985Pubmed ID
3930315DOI
10.1016/0012-1606(85)90502-0Scopus ID
2-s2.0-0022405709 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
Murine embryonal carcinoma (EC) cells can be stimulated to differentiate by several chemical inducers. Since the response of EC cells to induction is likely to occur shortly after exposure to the inducer, we report here the changes that occur in polyamine levels in a number of EC cell lines shortly after exposure to two chemical stimuli, alpha-difluoromethylornithine (DFMO) and retinoic acid (RA). Our results suggest that polyamine levels are important in determining the state of EC cell differentiation, but that reduction in these levels alone is not sufficient to induce differentiation in all the EC cell lines tested. Also, it is apparent that RA does influence levels of polyamines. However, this influence does not seem to be mediated through direct interaction with ODCase.
Author List
Kelly M, McCann PP, Schindler JMESH terms used to index this publication - Major topics in bold
AnimalsCell Differentiation
Cell Line
Eflornithine
Kinetics
Mice
Ornithine
Ornithine Decarboxylase
Polyamines
Teratoma
Tretinoin
