Modeling oxygen and carbon dioxide transport and exchange using a closed loop circulatory system. Adv Exp Med Biol 2008;614:353-60
Date
02/23/2008Pubmed ID
18290346Pubmed Central ID
PMC3377501DOI
10.1007/978-0-387-74911-2_39Scopus ID
2-s2.0-84934440804 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
The binding and buffering of O2 and CO2 in the blood influence their exchange in lung and tissues and their transport through the circulation. To investigate the binding and buffering effects, a model of blood-tissue gas exchange is used. The model accounts for hemoglobin saturation, the simultaneous binding of O2, CO2, H+, 2,3-DPG to hemoglobin, and temperature effects. Invertible Hill-type saturation equations facilitate rapid calculation of respiratory gas redistribution among the plasma, red blood cell and tissue that occur along the concentration gradients in the lung and in the capillary-tissue exchange regions. These equations are well-suited to analysis of transients in tissue metabolism and partial pressures of inhaled gas. The modeling illustrates that because red blood cell velocities in the flowing blood are higher than plasma velocities after a transient there can be prolonged differences between RBC and plasma oxygen partial pressures. The blood-tissue gas exchange model has been incorporated into a higher level model of the circulatory system plus pulmonary mechanics and gas exchange using the RBC and plasma equations to account for pH and CO2 buffering in the blood.
Author List
Carlson BE, Anderson JC, Raymond GM, Dash RK, Bassingthwaighte JBAuthor
Ranjan K. Dash PhD Professor in the Biomedical Engineering department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBiological Transport, Active
Carbon Dioxide
Computer Simulation
Diphosphoglyceric Acids
Erythrocytes
Hemoglobins
Humans
Hydrogen-Ion Concentration
Kinetics
Models, Cardiovascular
Oxygen
Partial Pressure
Protons
Pulmonary Gas Exchange
Respiratory Transport
Temperature
