Early uptake of 99mTc-C2A in the acute phase of myocardial infarction as a prognostic indicator for follow-up cardiac dysfunction. Nucl Med Commun 2008 Sep;29(9):764-9
Date
08/05/2008Pubmed ID
18677202DOI
10.1097/MNM.0b013e3283025085Scopus ID
2-s2.0-53149098653 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
OBJECTIVE: The C2A domain of Synaptotagmin I is a molecular probe for the specific imaging of cell death. Here we test the hypothesis that the uptake of 99mTc-C2A in the acute phase of an infarction is associated with cardiac dysfunction in follow-ups.
METHODS: The left coronary artery was occluded in Sprague-Dawley rats for 0, 10, 20, and 30 min. 99mTc-C2A was injected intravenously at 2 h of reperfusion. Anterior planar images were acquired with one million counts on a gamma camera 3 h after injection. 99mTc-C2A uptake was calculated as the total counts in the left ventricle region minus blood pool signal. The in-vivo signal detected was correlated with wall motion score index at 1 and 3 weeks follow-ups measured by echocardiography.
RESULTS: 99mTc-C2A uptake was higher with increased ischemic time (2244+/-852, 4054+/-1223, and 6178+/-1451 for 10, 20, and 30 min ischemia, analysis of variance P<0.001). A significant correlation was found between 99mTc-C2A uptake and wall motion score index at 1 week (R=0.800, P=0.0006) and 3 weeks (R=0.810, P=0.0008).
CONCLUSION: In this ischemia/reperfusion model, 99mTc-C2A uptake in the acute phase was associated with functional abnormality at 1 and 3 weeks. This demonstrates the potential diagnostic and prognostic value of 99mTc-C2A as a novel imaging agent.
Author List
Zhu X, Migrino RQ, Hellman RS, Brahmbhatt T, Zhao MMESH terms used to index this publication - Major topics in bold
AnimalsEchocardiography
Male
Motion
Myocardial Infarction
Myocardial Reperfusion
Organotechnetium Compounds
Prognosis
Radiopharmaceuticals
Rats
Rats, Sprague-Dawley
Recombinant Fusion Proteins
Reperfusion Injury
Synaptotagmins
Technetium
Time Factors
