Postglomerular vasoconstriction to angiotensin II and norepinephrine depends on intracellular calcium release. Gen Pharmacol 2000 Jun;34(6):409-15
Date
08/03/2001Pubmed ID
11483290DOI
10.1016/s0306-3623(01)00078-7Scopus ID
2-s2.0-0034434598 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
The current study was performed to determine the effect of calcium store depletion with cyclopiazonic acid (CPA) on the pre- and postglomerular vasoconstrictor responses to angiotensin II (ANG II) and norepinephrine (NE). CPA treatment significantly attenuated the afferent arteriolar response to 10 nM ANG II by 51% and to 1000 nM NE by 19%. Efferent arteriolar responses to ANG II and NE were also greatly attenuated in the presence of CPA. These data demonstrate that afferent and efferent arteriolar responses to ANG II and NE depend on release of calcium from CPA-sensitive intracellular stores. Furthermore, the postglomerular response to these agents exhibits a greater dependency on calcium release from intracellular stores.
Author List
Imig JD, Cook AK, Inscho EWMESH terms used to index this publication - Major topics in bold
Angiotensin IIAnimals
Arterioles
Calcium
Indoles
Kidney Glomerulus
Male
Models, Animal
Norepinephrine
Rats
Rats, Sprague-Dawley
Time Factors
Vasoconstriction
Vasoconstrictor Agents
