Faculty Collaboration Database

High-Resolution Imaging of Intraretinal Structures in Active and Resolved Central Serous Chorioretinopathy. Invest Ophthalmol Vis Sci 2017 Jan 01;58(1):42-49

Date

01/06/2017

Pubmed ID

28055101

Pubmed Central ID

PMC5225998

DOI

10.1167/iovs.16-20351

Scopus ID

2-s2.0-85009084218 (requires institutional sign-in at Scopus site)   22 Citations

Abstract

PURPOSE: We improved our understanding of central serous chorioretinopathy (CSC), we performed an analysis of noninvasive, high-resolution retinal imaging in patients with active and resolved CSC.

METHODS: Adaptive optics scanning light ophthalmoscopy (AOSLO) and spectral-domain optical coherence tomography (SD-OCT) were performed on five subjects with CSC. A custom AOSLO system was used to simultaneously collect confocal and split-detector images. Spectral domain-OCT volume scans were used to create en face views of various retinal layers, which then were compared to montaged AOSLO images after coregistration.

RESULTS: Three distinct types of intraretinal hyperreflective clusters were seen with AOSLO. These clusters had a well-demarcated, round, and granular appearance. Clusters in active CSC over areas of serous retinal detachment were termed type-1. They were found primarily in the outer nuclear layer (ONL) and were associated with large defects in the photoreceptor mosaic and ellipsoid zone. Clusters in areas where the retina had reattached were termed type-2. They also were located primarily in the ONL but showed stability in location over a period of at least 8 months. Smaller clusters in the inner retina along retinal capillaries were termed type-3.

CONCLUSIONS: Retinal imaging in CSC using en face OCT and AOSLO allows precise localization of intraretinal structures and detection of features that cannot be seen with SD-OCT alone. These findings may provide greater insight into the pathophysiology of the active and resolved phases of the disease, and support the hypothesis that intraretinal hyperreflective foci on OCT in CSC are cellular in nature.

Author List

Vogel RN, Langlo CS, Scoles D, Carroll J, Weinberg DV, Kim JE

Authors

Joseph J. Carroll PhD Director, Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin
Christopher Langlo MD, PhD Assistant Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Central Serous Chorioretinopathy
Fluorescein Angiography
Follow-Up Studies
Fovea Centralis
Fundus Oculi
Humans
Image Enhancement
Optics and Photonics
Retinal Photoreceptor Cell Inner Segment
Retinal Photoreceptor Cell Outer Segment
Time Factors
Tomography, Optical Coherence