Faculty Collaboration Database

Towards a field-compatible optical spectroscopic device for cervical cancer screening in resource-limited settings: effects of calibration and pressure. Opt Express 2011 Sep 12;19(19):17908-24

Date

09/22/2011

Pubmed ID

21935155

DOI

10.1364/OE.19.017908

Scopus ID

2-s2.0-80052735431 (requires institutional sign-in at Scopus site)   17 Citations

Abstract

Quantitative optical spectroscopy has the potential to provide an effective low cost, and portable solution for cervical pre-cancer screening in resource-limited communities. However, clinical studies to validate the use of this technology in resource-limited settings require low power consumption and good quality control that is minimally influenced by the operator or variable environmental conditions in the field. The goal of this study was to evaluate the effects of two sources of potential error: calibration and pressure on the extraction of absorption and scattering properties of normal cervical tissues in a resource-limited setting in Leogane, Haiti. Our results show that self-calibrated measurements improved scattering measurements through real-time correction of system drift, in addition to minimizing the time required for post-calibration. Variations in pressure (tested without the potential confounding effects of calibration error) caused local changes in vasculature and scatterer density that significantly impacted the tissue absorption and scattering properties Future spectroscopic systems intended for clinical use, particularly where operator training is not viable and environmental conditions unpredictable, should incorporate a real-time self-calibration channel and collect diffuse reflectance spectra at a consistent pressure to maximize data integrity.

Author List

Chang VT, Merisier D, Yu B, Walmer DK, Ramanujam N

Author

Bing Yu PH.D. Assistant Professor of Biomedical Engineering in the Biomedical Engineering department at Marquette University

MESH terms used to index this publication - Major topics in bold

Acetic Acid
Adult
Calibration
Early Detection of Cancer
Female
Haiti
Humans
Middle Aged
Monte Carlo Method
Optical Devices
Phantoms, Imaging
Pressure
Sensitivity and Specificity
Spectrum Analysis
Uterine Cervical Neoplasms
Vaginal Smears