Faculty Collaboration Database

Early onset salt-sensitive hypertension in bradykinin B(2) receptor null mice. Hypertension 1999 Aug;34(2):176-80

Date

08/24/1999

Pubmed ID

10454437

DOI

10.1161/01.hyp.34.2.176

Scopus ID

2-s2.0-0032819548 (requires institutional sign-in at Scopus site)   66 Citations

Abstract

Kinins have been implicated in the hemodynamic adaptation to postnatal life. The present study examined the impact of bradykinin B(2) receptor (B(2)R) gene disruption on the postnatal changes in blood pressure (BP) and the susceptibility to early onset salt-sensitive hypertension in mice. B(2)R null (-/-) and wild-type (+/+) mice were fed normal (NS, 1% NaCl) or high (HS, 5% NaCl) salt diets during pregnancy. After birth, the pups remained with their mothers until they were weaned and were subsequently continued on the respective maternal salt intake until 4 months of age. The age-related changes at 3 and 4 months in tail-cuff BP and anesthetized mean arterial pressure at 4 months were not different in NS/B(2)R(-/-) and NS/B(2)R(+/+) mice. However, there was a mild increase in BP in NS/B(2)R(-/-) at 2 months versus NS/B(2)R(+/+). In contrast, HS/B(2)R(-/-) mice manifested early onset and persistent elevations of tail-cuff BP (P<0.05) at 2, 3, and 4 months versus other groups. MAP was also higher in HS/B(2)R(-/-) than HS/B(2)R(+/+), NS/B(2)R(-/-), and NS/B(2)R(+/+) (91+/-3 versus 75+/-5, 74+/-2, and 70+/-2 mm Hg, respectively; P<0.05). Kidney renin and angiotensin type 1 receptor mRNA levels were not different. Additional studies showed that a delay in the initiation of HS until after birth was accompanied by later development of hypertension, although postnatal discontinuation of HS resulted in a gradual return of BP to normal values by 4 months of age. The results demonstrate that (1) kinins protect the developing animal from salt-sensitive hypertension, (2) lack of B(2)R from early development does not alter the maturation of BP under conditions of normal sodium intake, and (3) exposure to a HS diet during fetal life is not sufficient in itself to induce long-term hypertension in either wild-type or B(2)R null mice.

Author List

Cervenka L, Harrison-Bernard LM, Dipp S, Primrose G, Imig JD, El-Dahr SS

MESH terms used to index this publication - Major topics in bold

Age Factors
Angiotensin II
Animals
Animals, Newborn
Blood Pressure
Blotting, Northern
Body Weight
Data Interpretation, Statistical
Female
Hypertension
Kallikrein-Kinin System
Kidney
Male
Mice
Mice, Knockout
Pregnancy
RNA, Messenger
Radioimmunoassay
Receptors, Angiotensin
Receptors, Bradykinin
Renin-Angiotensin System
Sodium Chloride, Dietary