Localization of T and B lymphocytes to the white pulp of the spleen is independent of L-, E-, and P-selectin. ScientificWorldJournal 2003 Jun 09;3:484-96
Date
07/09/2003Pubmed ID
12847299Pubmed Central ID
PMC5974887DOI
10.1100/tsw.2003.42Scopus ID
2-s2.0-1542752975 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
T and B cell interactions are thought to be of prime importance in the generation of a humoral immune response. These interactions are thought to take place in the secondary lymphoid organs. The largest of which is the spleen. While the pathways involved in lymphocyte migration into other secondary lymphoid organs have been unraveled, very little is understood about T and B cell migration to the spleen. We report that adoptively transferred T lymphocytes appear more rapidly within the lymphoid compartment of the spleen than do B lymphocytes. Indeed, half of the transferred T lymphocytes in the spleen appear within the white pulp by 1.4 hours. B lymphocytes take nearly 4.3 hours to achieve the same level of accumulation. In addition, T lymphocyte arrival is fucoidan sensitive, while B cells are not affected by this polysaccharide. Finally, we show that neither L-, E-, or P-selectin appears to play a significant role in the accumulation of lymphocytes in the white pulp.)
Author List
Grayson MH, Chaplin DDMESH terms used to index this publication - Major topics in bold
Adoptive TransferAnimals
B-Lymphocytes
Cell Movement
E-Selectin
L-Selectin
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Mice, Mutant Strains
P-Selectin
Polysaccharides
Spleen
T-Lymphocytes
