Reduced electrogenic sodium-potassium pump in arterioles during renovascular hypertension. Hypertension 1987 Jun;9(6 Pt 2):III86-90
Date
06/01/1987Pubmed ID
2439454DOI
10.1161/01.hyp.9.6_pt_2.iii86Scopus ID
2-s2.0-0023259281 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
The goal of this study was to assess the role of the electrogenic Na+-K+ pump in controlling active tone in cremasteric arterioles of normotensive hamsters and hamsters with bilateral (two-kidney, two figure-8) Grollman hypertension. Arterioles of both groups exhibited a large transient dilation when the Na+-K+ pump was stimulated by superfusing the cremaster muscle with physiological salt solution containing 15 mM K+ after 20 minutes of 0 mM K+ superfusion. Arteriolar dilation in response to 15 mM K+ was significantly smaller in the hypertensive animals than in sham-operated controls. Ouabain (10(-5) M and 10(-3) M) inhibited arteriolar dilation in response to 15 mM K+ in both groups of animals. Resting diameters, total active tone (assessed by application of 10(-4) M adenosine), and arteriolar responses to inhibition of the Na+-K+ pump by superfusion with 0 mM K+ or ouabain were not significantly different in normotensive and hypertensive animals. These data indicate that an electrogenic Na+-K+ pump can regulate active tone in cremasteric arterioles, and that the maximum response of this pump to stimulation with 15 mM K+ is reduced in arterioles of hamsters with two-kidney Grollman hypertension.
Author List
Lombard JH, Joyner WL, Stekiel WJAuthor
Julian Lombard PhD, MS Emeritus Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdenosineAnimals
Arteries
Arterioles
Cricetinae
Electrophysiology
Hypertension, Renovascular
Ion Channels
Male
Mesocricetus
Osmolar Concentration
Ouabain
Perfusion
Potassium
Rest
Sodium
Tetrodotoxin
