Faculty Collaboration Database

Genetic variation influences the B-cell response to immunization with a pneumococcal polysaccharide conjugate vaccine. Infect Immun 2003 Sep;71(9):5402-6

Date

08/23/2003

Pubmed ID

12933893

Pubmed Central ID

PMC187339

DOI

10.1128/IAI.71.9.5402-5406.2003

Scopus ID

2-s2.0-0042324125 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

CBA/J mice immunized with pneumococcal 23F-CRM(197) vaccine produce significantly lower titers of 23F-specific antibodies and fewer 23F-specific antibody-secreting cells (ASC) than did BALB/c or (CBA/J x BALB/c)F(1) (CCBAF(1)) mice. The reduced 23F-specific titers of CBA/J versus BALB/c or CCBAF(1) mice are presumably related to lower frequencies of 23F-specific ASC influenced by genetic variation.

Author List

McCool TL, Schreiber JR, Greenspan NS

MESH terms used to index this publication - Major topics in bold

Animals
Antibodies, Bacterial
B-Lymphocytes
Genetic Variation
Immunization
Mice
Mice, Inbred BALB C
Mice, Inbred CBA
Pneumococcal Vaccines
Species Specificity
Streptococcus pneumoniae
Vaccines, Conjugate