A family cluster of five cases of group A streptococcal pneumonia. Pediatrics 2003 Jul;112(1 Pt 1):e61-5
Date
07/03/2003Pubmed ID
12837907DOI
10.1542/peds.112.1.e61Scopus ID
2-s2.0-0642283824 (requires institutional sign-in at Scopus site) 24 CitationsAbstract
A cluster of 5 family members, a mother and 4 children, were hospitalized for severe group A Streptococcus (GAS) pneumonia. Three family members had complications: sepsis (1), empyema (2), and a sterile parapneumonic effusion (1). Two additional family members had symptoms of upper respiratory tract infection, and 1 was hospitalized for these symptoms. GAS was isolated from the blood of 1 patient, the pleural fluid of 2 patients, and the oropharynx of 6 patients. Pulsed field gel electrophoresis testing revealed an identical deoxyribonucleic acid pattern in all 7 isolates. Genotyping revealed the speA gene and serotyping the T-1, M-1 serotype in all isolates. This family cluster of invasive GAS disease is the largest reported to date, with an attack rate of 41.7% (5 of 12 family members). This report provides further support for antibiotic prophylaxis of close contacts of individuals with invasive GAS disease.
Author List
Roy S, Kaplan EL, Rodriguez B, Schreiber JR, Salata RA, Palavecino E, John CCMESH terms used to index this publication - Major topics in bold
Anti-Bacterial AgentsChild
Contact Tracing
DNA, Bacterial
Disease Outbreaks
Disease Transmission, Infectious
Drug Therapy, Combination
Electrophoresis, Gel, Pulsed-Field
Empyema, Pleural
Family Health
Female
Genotype
Humans
Male
Middle Aged
Pharyngitis
Pneumonia, Bacterial
Serotyping
Shock, Septic
Streptococcal Infections
Streptococcus pyogenes
