Cross-sectional and longitudinal studies of naturally occurring antibodies to Pseudomonas aeruginosa in cystic fibrosis indicate absence of antibody-mediated protection and decline in opsonic quality after infection. J Infect Dis 1995 Aug;172(2):453-61
Date
08/01/1995Pubmed ID
7622889DOI
10.1093/infdis/172.2.453Scopus ID
2-s2.0-0029129137 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
Most patients with cystic fibrosis (CF) develop chronic endobronchial infection with mucoid Pseudomonas aeruginosa. It has been suggested that opsonic antibodies to the mucoid exopolysaccharide of P. aeruginosa protect older CF patients (> 12 years of age) who have remained free of colonization by this organism. Serum antibodies from chronically infected CF patients had greater total complement-dependent opsonic activity than did those of older noncolonized patients (P < .02), but when bound antibody was equalized, opsonic quality was greater for the latter group (P < .03). In longitudinal studies, antibody titers to mucoid P. aeruginosa rose greatly after initial infection, but opsonic quality declined (P = .002). Twenty CF patients who passed age 12 free of P. aeruginosa colonization developed chronic P. aeruginosa lung infection at ages 14-35 years. Thus, naturally occurring antibodies do not protect CF patients from P. aeruginosa infection, and opsonic quality of serum antibodies deteriorates as infection becomes established.
Author List
Tosi MF, Zakem-Cloud H, Demko CA, Schreiber JR, Stern RC, Konstan MW, Berger MMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Antibodies, Bacterial
Antibody Affinity
Antigens, Bacterial
Child
Child, Preschool
Complement Activation
Cross-Sectional Studies
Cystic Fibrosis
Glycosaminoglycans
Humans
Infant
Longitudinal Studies
Lung Diseases
Opsonin Proteins
Phagocytosis
Polysaccharides, Bacterial
Pseudomonas Infections
Pseudomonas aeruginosa
Retrospective Studies
