The spread of multiply resistant Streptococcus pneumoniae at a day care center in Ohio. J Infect Dis 1992 Dec;166(6):1346-53
Date
12/01/1992Pubmed ID
1431252DOI
10.1093/infdis/166.6.1346Scopus ID
2-s2.0-11944269260 (requires institutional sign-in at Scopus site) 364 CitationsAbstract
Streptococcus pneumoniae, type 23F, resistant to penicillin (MIC, 2 micrograms/mL) and multiple other antimicrobic agents, was isolated from middle ear fluid of a child with otitis media attending a day care center in Ohio. To determine the extent of spread of this strain, nasopharyngeal culture surveys were done, and 52 carriers were identified among 250 children attending the index day care center. No carriers were found among 121 children at two other day care centers in the same urban area. Use of prophylactic doses of antibiotics (P < .001) and frequent use of antibiotics (P < 0.001) were risk factors for nasopharyngeal carriage. Carriers were more likely to have had frequent otitis media episodes (P < .02) and otitis media not responsive to antimicrobial therapy (P < .001). Strategies to limit the spread of highly resistant pneumococcal strains should include encouraging judicious use of antimicrobic agents and reevaluating indications for prophylactic use of antimicrobic agents.
Author List
Reichler MR, Allphin AA, Breiman RF, Schreiber JR, Arnold JE, McDougal LK, Facklam RR, Boxerbaum B, May D, Walton ROMESH terms used to index this publication - Major topics in bold
AdultAge Factors
Carrier State
Child
Child Day Care Centers
Child, Preschool
Drug Resistance, Microbial
Erythromycin Ethylsuccinate
Humans
Infant
Nasopharynx
Ohio
Otitis Media
Penicillin Resistance
Pneumococcal Infections
Rifampin
Risk Factors
Streptococcus pneumoniae
