Candida antigen detection in two premature neonates with disseminated candidiasis. Pediatrics 1984 Nov;74(5):838-41
Date
11/01/1984Pubmed ID
6436783Scopus ID
2-s2.0-0021739009 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
Two premature neonates with birth weight less than 1,200 g developed systemic candidiasis during treatment with multiple antibiotics and parenteral hyperalimentation. Clinical findings included signs of necrotizing enterocolitis in one patient and multiple fungal renal cortical abscesses in the other. The Candida antigen, mannan, was present in the sera of both patients at the time of clinical deterioration. Multiple blood cultures and urine and stool samples from both patients grew Candida albicans. Systemic antifungal therapy was given for a 6-week period and was associated with prolonged antigenemia despite negative findings on follow-up cultures. Antifungal therapy was stopped soon after antigen was no longer detected. Both patients recovered without evidence of further fungal infection. Candida antigen detection may be useful in the diagnosis and follow-up of premature infants with disseminated candidiasis.
Author List
Schreiber JR, Maynard E, Lew MAMESH terms used to index this publication - Major topics in bold
Amphotericin BAntigens, Fungal
Candida
Candidiasis
Enterocolitis
Enzyme-Linked Immunosorbent Assay
Female
Humans
Infant, Newborn
Infant, Premature, Diseases
Male
Mannans
Parenteral Nutrition, Total
Postoperative Complications
