Multi-visceral resection of pancreatic VIPoma in a patient with sinistral portal hypertension. World J Surg Oncol 2008 Jul 28;6:80
Date
07/30/2008Pubmed ID
18662399Pubmed Central ID
PMC2517072DOI
10.1186/1477-7819-6-80Scopus ID
2-s2.0-49949101159 (requires institutional sign-in at Scopus site) 15 CitationsAbstract
BACKGROUND: VIPomas are rare neuroendocrine tumors poorly described in the literature. Aggressive resection of patients with advanced VIPoma neuroendocrine tumors has rarely been reported.
CASE PRESENTATION: A 46 year old women presented with abdominal pain and diarrhea. A three-dimensional (3-D) pancreas protocol computed tomography scan revealed an 18 x 12 cm pancreatic VIPoma abutting the liver, stomach, spleen, left adrenal, colon that also invaded the distal duodenum - proximal jejunum at the ligament of Treitz in association with sinistral portal hypertension. Following preoperative proximal splenic artery embolization, the patient with underwent successful en bloc resection of the locally advanced VIPoma in conjunction with a diaphragmatic resection, total gastrectomy, splenectomy, left adrenalectomy, as well as small and large bowel resection. The estimated blood loss was 500 ml. All margins were negative (R0 resection). The patient is alive and disease-free.
CONCLUSION: This case illustrates the role of aggressive resection of pancreatic neuroendocrine tumors and highlights several key technical points that allowed for successful resection.
Author List
Joyce DL, Hong K, Fishman EK, Wisell J, Pawlik TMMESH terms used to index this publication - Major topics in bold
AdrenalectomyFemale
Humans
Hypertension, Portal
Middle Aged
Pancreatectomy
Pancreatic Neoplasms
Pancreaticoduodenectomy
Splenectomy
Tomography, X-Ray Computed
Vipoma
