Experience with the symbion total artificial heart as a bridge to transplantation. Ann Thorac Surg 1992 Feb;53(2):282-8
Date
02/01/1992Pubmed ID
1731670DOI
10.1016/0003-4975(92)91334-6Scopus ID
2-s2.0-0026527116 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
From December 1985 through January 1991, 9 patients underwent bridging to transplantation using a Symbion J-7-70 total artificial heart. There were 4 female and 5 male patients aged 31 +/- 14 years (range, 15 to 52 years). Five patients were supported on an intraaortic balloon pump before total artificial heart support, and 2 had biventricular assist devices as well. Total artificial heart support was maintained for 17 +/- 12 days (range, 4 to 44 days); all patients underwent transplantation. Three patients died after transplantation on day 0 (primary donor organ failure), 25 (acute rejection), and 256 (multiorgan failure). The remainder were discharged at 41 +/- 32 days (range, 13 to 101 days). One patient died 28 months after transplantation of late acute rejection. Actuarial 1-year and 3-year survival is 67% and 55%. There were no surgical wound infections. Problems encountered in the J-7-70 period and the period after transplantation were for the most part related to patient condition in the period before implantation. The Symbion J-7-70 total artificial heart is an effective device for total circulatory support in patients with end-stage cardiogenic shock when an organ donor is not available. Organ system failure and infection before implantation may persist into the transplantation period resulting in long-term complications, increased mortality, and prolonged hospital stay; therefore, early implantation of the device when indicated should be applied.
Author List
Emery RW, Joyce LD, Prieto M, Johnson K, Goldenberg IF, Pritzker MRMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Cardiomyopathies
Cause of Death
Coronary Disease
Female
Graft Rejection
Heart Transplantation
Heart, Artificial
Humans
Male
Middle Aged
Prosthesis Design
Survival Analysis
Virus Diseases
