Surface sulphydryl groups and hexose monophosphate pathway activity in resting human polymorphonuclear leucocytes. Br J Haematol 1976 Jun;33(2):205-11
Date
06/01/1976Pubmed ID
178344DOI
10.1111/j.1365-2141.1976.tb03531.xScopus ID
2-s2.0-0017182659 (requires institutional sign-in at Scopus site) 10 CitationsAbstract
The role of surface -SH groups on the hexose monophosphate pathway activity in resting human polymorphonuclear leucocytes was studied. Endotoxin, taurocholic acid and concanvalin A stimulated [I-14C]glucose oxidation to a greater degree than [6-14C]glucose oxidation. The stimulation of glucose-I-C-oxidation by endotoxin, taurocholic acid and concanavalin A could be prevented by p-chloromercurybenzene sulphonic acid, an inhibitor of surface -SH groups. In contrast, polymorphonuclear leucocytes from four patients with chronic granulomatous disease failed to show stimulation of glucose-I-C-oxidation by endotoxin, taurocholic acid or concanavalin A.
Author List
Tsan MF, Newman B, Chusid MJ, Wolff SM, McIntyre PAMESH terms used to index this publication - Major topics in bold
4-ChloromercuribenzenesulfonateBiological Transport
Blood Glucose
Cell Membrane Permeability
Colchicine
Concanavalin A
Endotoxins
Granulomatous Disease, Chronic
Hexosephosphates
Humans
Lectins
Neutrophils
Sulfhydryl Compounds
Surface Properties
