Pediatric Gynecologic Cancers. Curr Oncol Rep 2017 Jul;19(7):44
Date
05/16/2017Pubmed ID
28501984DOI
10.1007/s11912-017-0604-7Scopus ID
2-s2.0-85019267655 (requires institutional sign-in at Scopus site) 28 CitationsAbstract
PURPOSE OF REVIEW: Three primary categories of gynecologic cancer are found in pediatric and adolescent patients: stromal carcinomas including juvenile granulosa cell tumors and Sertoli-Leydig cell tumors, rhabdomyosarcomas arising from the vagina and cervix (sarcoma botryoides), and ovarian germ cell tumors which comprise a wide range of histologies. These entities are rare and treatment approaches have focused on decreasing late effects of chemotherapy treatment. Here, we review presentation, histologic classifications, diagnosis, and treatment recommendations for pediatric gynecologic cancers.
RECENT FINDINGS: Event-free and overall survival for these cancers is high, and the goals of treatment are minimization of morbidity and preservation of fertility with unilateral salpingo-oophorectomies and limited staging. Surveillance of tumor markers after surgery is helpful in monitoring for disease progression and adjuvant chemotherapy is often reserved for patients at recurrence. Recent literature supports avoiding chemotherapy even in high-grade germ cell tumors in the pediatric population.
Author List
Pommert L, Bradley WAuthor
William H. Bradley MD Professor in the Obstetrics and Gynecology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentBiomarkers, Tumor
Child
Disease-Free Survival
Female
Genital Neoplasms, Female
Granulosa Cell Tumor
Humans
Rhabdomyosarcoma
Sarcoma
Sertoli-Leydig Cell Tumor
Vaginal Neoplasms
