Faculty Collaboration Database

Protective effect of Piper longum fruit ethanolic extract on radiation induced damages in mice: a preliminary study. Fitoterapia 2005 Dec;76(7-8):649-55

Date

10/26/2005

Pubmed ID

16243448

DOI

10.1016/j.fitote.2005.08.008

Scopus ID

2-s2.0-28044460109 (requires institutional sign-in at Scopus site)   34 Citations

Abstract

The radioprotective property of an ethanolic extract of Piper longum fruits (EEPLF) was investigated in Swiss mice. The white blood cell (WBC) count in irradiated control mice was drastically reduced to 1900 cells/mm3 on third day but in treated animals the count was 2783.3 cells/mm3. The number of bone marrow cells and alpha-esterase positive cells was also enhanced by the EEPLF administration (16.7 x 10(6) cells/femur and 946.5/4000 cells, respectively) when compared to the radiation exposed control animals (12.2 x 10(6) cells/femur and 693.5/4000 cells, respectively). EEPLF reduced the elevated levels of glutathione pyruvate transaminase (GPT), alkaline phosphatase (ALP), and lipid peroxidation (LPO) in liver and serum of radiation treated animals. The extract administration also increased the reduced glutathione (GSH) production to offer the radioprotection.

Author List

Sunila ES, Kuttan G

Author

Sunila Pradeep PhD Associate Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Alkaline Phosphatase
Animals
Bone Marrow Cells
Fruit
Glutathione
Leukocyte Count
Lipid Peroxidation
Liver
Mice
Piper
Plant Extracts
Radiation-Protective Agents
Whole-Body Irradiation