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Early effects of experimental diabetes on central catecholamine concentrations. Brain Res Bull 1988 May;20(5):651-4

Date

05/01/1988

Pubmed ID

3133085

DOI

10.1016/0361-9230(88)90226-2

Scopus ID

2-s2.0-0024162567 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

Six days after induction of diabetes norepinephrine (NE), 3,4-dihydroxyphenylalanine and dopamine concentrations were determined in spinal cord, cerebellum, pons/medulla oblongata and the remaining brain of diabetic rats. Only cerebellar NE levels were significantly increased by 21% compared to age-matched controls. This effect was not seen when diabetic rats received insulin replacement therapy. Fifty-two days after induction of diabetes cerebellar NE levels in diabetic rats were further increased (+37%), implying an enduring and progressive effect. The data show that even with a short period of uncontrolled diabetes central neurochemical alterations occur.

Author List

Wesselmann U, Konkol RJ, Roerig DL, Harder DR

MESH terms used to index this publication - Major topics in bold

Animals
Brain
Diabetes Mellitus, Experimental
Dihydroxyphenylalanine
Dopamine
Male
Norepinephrine
Rats
Rats, Inbred Lew
Spinal Cord