The human complement C4B/steroid 21-hydroxylase (CYP21) and complement C4A/21-hydroxylase pseudogene (CYP21P) intergenic sequences: comparison and identification of possible regulatory elements. Biochem Biophys Res Commun 1992 Jul 15;186(1):256-62
Date
07/15/1992Pubmed ID
1385946DOI
10.1016/s0006-291x(05)80801-0Scopus ID
2-s2.0-0026707238 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
We determined the 1.8 kb intergenic sequences between the human complement C4B gene and the active steroid 21-hydroxylase gene in two subjects, and between the C4A gene and the steroid 21-hydroxylase pseudogene in one subject. Comparison of these sequences with each other and with published homologues revealed no differences which were unique to either intergenic region. Sequence analysis revealed two copies of an AGGTCA motif in all sequences. This motif is common to steroidogenic enzyme gene promoters and to the response elements for nuclear hormone receptors. Similarities with human enhancers were also found.
Author List
Donohoue PA, Collins MMMESH terms used to index this publication - Major topics in bold
Bacteriophage lambdaBase Sequence
Blotting, Southern
Cloning, Molecular
Complement C4a
DNA
DNA Probes
Humans
Introns
Molecular Sequence Data
Oligodeoxyribonucleotides
Polymerase Chain Reaction
Pseudogenes
Regulatory Sequences, Nucleic Acid
Steroid 21-Hydroxylase
