Medical College of Wisconsin
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Adaptive optics imaging of inherited retinal diseases. Br J Ophthalmol 2018 Aug;102(8):1028-1035

Date

11/17/2017

Pubmed ID

29141905

Pubmed Central ID

PMC6059037

DOI

10.1136/bjophthalmol-2017-311328

Scopus ID

2-s2.0-85047410220 (requires institutional sign-in at Scopus site)   80 Citations

Abstract

Adaptive optics (AO) ophthalmoscopy allows for non-invasive retinal phenotyping on a microscopic scale, thereby helping to improve our understanding of retinal diseases. An increasing number of natural history studies and ongoing/planned interventional clinical trials exploit AO ophthalmoscopy both for participant selection, stratification and monitoring treatment safety and efficacy. In this review, we briefly discuss the evolution of AO ophthalmoscopy, recent developments and its application to a broad range of inherited retinal diseases, including Stargardt disease, retinitis pigmentosa and achromatopsia. Finally, we describe the impact of this in vivo microscopic imaging on our understanding of disease pathogenesis, clinical trial design and outcome metrics, while recognising the limitation of the small cohorts reported to date.

Author List

Georgiou M, Kalitzeos A, Patterson EJ, Dubra A, Carroll J, Michaelides M

Author

Joseph J. Carroll PhD Director, Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Eye Diseases, Hereditary
Humans
Ophthalmoscopy
Optics and Photonics
Retinal Diseases