Lung tumor response in mice to metals and metal salts. Adv Exp Med Biol 1977;91:85-91
Date
01/01/1977Pubmed ID
564598DOI
10.1007/978-1-4684-0796-9_6Scopus ID
2-s2.0-0017639268 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
Two studies tested the ability of metals and their salts to produce lung tumors in strain A mice. Of 13 compounds examined, lead subacetate, manganous sulfate, molybdenum trioxide, and nickelous acetate elicited a weakly carcinogenic response following intraperitoneal injection. Nine metallic compounds were negative. There was no evidence of cocarcinogenic effect between metals and the chemical carcinogen, 3-methylcholanthrene. On the basis of these and other data, recommendation is made for further investigations in metal carcinogenesis.
Author List
Shimkin MB, Stoner GD, Theiss JCMESH terms used to index this publication - Major topics in bold
AnimalsCocarcinogenesis
Injections, Intraperitoneal
Lead
Lung Neoplasms
Manganese Poisoning
Metals
Methylcholanthrene
Mice
Mice, Inbred A
Molybdenum
Neoplasms, Experimental
Nickel
