Faculty Collaboration Database

Initial equilibration of albumin in rabbit hindpaw skin and lymph. Am J Physiol 1988 Jan;254(1 Pt 2):H89-101

Date

01/01/1988

Pubmed ID

3337263

DOI

10.1152/ajpheart.1988.254.1.H89

Scopus ID

2-s2.0-0023849525 (requires institutional sign-in at Scopus site)   15 Citations

Abstract

We compared initial plasma to extravascular and plasma to lymph equilibrations of 125I-labeled rabbit albumin in hindpaw heelskin of anesthetized rabbits during control conditions, increased venous pressure (IVP), and intra-arterial infusions of papaverine or bradykinin. Plasma tracer concentrations were maintained constant during the experiments. Control prenodal lymph specific activity relative to plasma specific activity (L*/P*) was significantly greater (P less than 0.01) than extravascular specific activity relative to plasma specific activity (M/P) following 3, 5.5, and 11 h of tracer infusion. Papaverine increased lymph flow and lymph albumin flux (LCL) 2.4-fold, without significantly changing the extravascular albumin mass (MA). IVP increased LCL 2.5-fold and decreased MA 25%. L*/P* at 3 h was twice control following papaverine. M*/P* at 3 h was not significantly affected by papaverine or IVP. Bradykinin increased LCL 10-fold and MA 2.3-fold. L*/P* and M*/P* were 3.1 and 4.3 times control, respectively. The data are consistent with extravascular albumin distributing into two pools that equilibrate with plasma at different rates. Papaverine and IVP affect the faster pool, whereas bradykinin affects both pools.

Author List

Powers MR, Wallace JR, Bell DR

MESH terms used to index this publication - Major topics in bold

Albumins
Algorithms
Animals
Bradykinin
Female
Hindlimb
Lymph
Male
Rabbits
Skin
Time Factors
Venous Pressure