The accuracy of alkaline phosphatase isoenzyme determination. J Gen Intern Med 1988;3(4):326-30
Date
07/01/1988Pubmed ID
3404293DOI
10.1007/BF02595789Scopus ID
2-s2.0-0023722352 (requires institutional sign-in at Scopus site)Abstract
Alkaline phosphatase isoenzyme determination (APID) is in common use despite evidence suggesting that the results correlate poorly with actual sites of disease. To assess the predictive value of this test in clinical practice, 99 APIDs performed on 94 patients were identified and the patients' charts were reviewed. Results of APID were compared with actual patient diagnoses as determined by other means. The liver isoenzyme fraction was not very accurate in predicting the presence of liver disease (positive predictive value 68%). In contrast, the bone isoenzyme fraction was insensitive (56%) but a positive test predicted bone disease well (positive predictive value 93%). The association of elevated transaminases with elevated alkaline phosphatase on a chemistry profile was as useful as APID in identifying liver disease, suggesting that APID should not be done in this setting. Using this information, APID can be helpful in the assessment of an ill patient with an elevated alkaline phosphatase.
Author List
Lamb GC, Roush GAuthor
Geoffrey Lamb MD Emeritus Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAlkaline Phosphatase
Bone Diseases
Clinical Enzyme Tests
Female
Humans
Isoenzymes
Liver Diseases
Male
Retrospective Studies
