Assessment of antimicrobial penetrance into the pancreatic juice in humans. Surg Gynecol Obstet 1986 Apr;162(4):313-6
Date
04/01/1986Pubmed ID
3485828Scopus ID
2-s2.0-0022568978 (requires institutional sign-in at Scopus site) 18 CitationsAbstract
The penetrance of mezlocillin, metronidazole and trimethoprim-sulfamethoxazole into the pancreatic juice of humans was measured in ten patients convalescing from acute pancreatitis at the time of endoscopic retrograde cholangiopancreatography. Therapeutic levels were obtained in the serum for all three antimicrobial agents; simultaneously aspirated nonbile stained pancreatic juice contained therapeutic levels of metronidazole and trimethoprim-sulfamethoxazole. Mezlocillin was not present in a therapeutic level in any patient with nonbile stained pancreatic fluid.
Author List
Wallace JR, Cushing RD, Bawdon RE, Sugawa C, Lucas CE, Ledgerwood AMMESH terms used to index this publication - Major topics in bold
Acute DiseaseCholangiopancreatography, Endoscopic Retrograde
Chromatography, High Pressure Liquid
Drug Combinations
Drug Evaluation
Humans
Metronidazole
Mezlocillin
Pancreatic Diseases
Pancreatic Ducts
Pancreatic Juice
Pancreatic Pseudocyst
Pancreatitis
Sulfamethoxazole
Trimethoprim
Trimethoprim, Sulfamethoxazole Drug Combination
